Question

S-Adenosylmethionine (abbreviated adoMet or SAM) is a methyl group donor in numerous metabolic pathways, including the metabolism of lipids and amino acids. Which of the following descriptions of S-adenosylmethionine are accurate? Check all that apply.
1) The transfer of the methyl group from adoMet to an acceptor yields S-adenosylhomocysteine.

2) The methyl group originally attached to the sulfur atom of methionine is transferred to an acceptor.

3) The adenosyl group is linked to methionine via a bond between C5 and the sulfur atom.

4) After ATP is cleaved, inorganic phosphate is added to C5 of the intermediate.

5) ATP is cleaved to ADP and Pi in S-adenosylmethionine synthesis.

Answer 1

Answer:

The following descriptions of S-adenosylmethionine are accurate

1) The transfer of the methyl group from adoMet to an acceptor yields S-adenosylhomocysteine.

2) The methyl group originally attached to the sulfur atom of methionine is transferred to an acceptor.

5) ATP is cleaved to ADP and Pi in S-adenosylmethionine synthesis.

Explanation:

This S-adenosyl-I-methionine act as a substrate material for various enzyme-catalysed reaction. This not only provides the methyl groups to the biological methylations,  but also it acts as precursor for the biosynthesis of the polyamines and the spermidine .Also in spermine present in the metal ion or the chelating compounds which is nicotianamine and also the phytosiderophores and among the plant hormones for ethylene a gaseous plant hormone. Adomet is the source for catalytic 5’- deoxyadenosyl radicals, produced by reaction by the superfamily of the radical AdoMet enzymes.