Disruption in protein homeostasis leads to the appearance and accumulation of intermediate nonnative conformations that tend to form oligomeric and aggregated species, which over time cause cellular injury..
I'm not sure what you're asking, but if you're looking for a word to describe this change its "mutation"
NOT EXACT DEFINITION: Diseases that can be passed from one living organism to the other. Two examples are flu and several STIs (such as herpes). Sorry I couldn’t think of any more :)