Agoraphobia is the fear of being out in the open. People with Agoraphobia are scared of leaving home, crowded places and places that escape would be difficult.
Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
The most likely diagnosis following the above listed symptoms is hemorrhoids.
<h3>What are hemorrhoids?</h3>
Hemorrhoids is defined as a disease that occur due to inflammation of the vein at the rectum. The inflammation at the rectal region is due to:
- Straining during bowel movements.
- Sitting for long periods of time on the toilet and
- Having chronic diarrhea or constipation.
Therefore, the likely diagnosis is hemorrhoids.
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Answer:
Im pretty sure it is 50% i am terribly sorry if its wrong but i like positive its that
Explanation:
