1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Komok [63]
3 years ago
8

The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3′ hydroxyl group (–OH)

. Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA.

Biology
1 answer:
Dima020 [189]3 years ago
6 0

Answer:

There won't be any functional viral DNA synthesis

Explanation:

First of all, you must consider that the HSV has a double-stranded, linear DNA genome. Furthermore, the DNA skeleton is made of the 5'-3' phosphodiester bond. In other words, the 5-phosphat of a nucleotide will bond the 3' OH of the Deoxyribose (see image).

Therefore, if you add a molecule which lacks the 3' OH, such as acyclovir, and has a similar chemical structure to a regular nucleotide, the DNA polimerase will be able to add acyclovir to the main backbone of the viral genome. All in all, you'd be ''cheating'' the DNA pol.

Hence, wherever acyclovir was integrated, there won't be any chance to form a 5'-3' phosphodiester bond. The protomolecule will not be stable and will soon be degradated.

You might be interested in
What connects the nitrogenous based to each other?
Keith_Richards [23]

Hello!

There are two possible answers to this. The one I'm assuming you're looking for is hydrogen bonds.

Hydrogen bonds are the bonds which hold together the double helix shape of DNA. These bonds result from a positive and negative charge drawing two molecules closer to each other. These bonds are generally seen as weak, however, since there are so many of these bonds (as there are so many nitrogenous bases in one strand of DNA), the double helix strand is fairly strong.

Hope this helps!

7 0
2 years ago
Please help me answer these questions!
Harrizon [31]
#6 is A. They are all composed of one or more cells.
7 0
3 years ago
Read 2 more answers
How is the flow of energy through a community different from the cycling from the matter?.
Paha777 [63]
Matter can be recycled, but energy cannot. Also, only 10% of the energy is passed through each trophic level.
4 0
3 years ago
The symmetry exhibited by adult echinoderms is ______________.
UNO [17]
The answer is radial
6 0
2 years ago
Can someone give me 4 examples of physical weathering
valkas [14]
Yes, sure!

1) Moving Water - Water, when running for a long period of time, can actually start to weather rocks.

2) <span>Ice wedging - Yep, this can cause rocks to weather as well. Water, when being constantly frozen and unfrozen weathers the rock due to the fact that water is able to expand.
</span>
3) Plant Roots - Ah, these little nutrient grabbers can certainly weather rocks over periods of time.

4) Winds - Winds can certainly physically weather the rocks, and it's probably the most common way they do.


<span>P.S. If this answer helped you, please, make sure to say "Thanks" just below my answer. It will help me a lot</span>
4 0
3 years ago
Other questions:
  • Wolves feed on a variety of large prey, including elk. Elk feed on shrubs and trees like aspen and cottonwood trees.
    10·2 answers
  • A couple with a newborn baby is troubled that the child does not resemble either of them. suspecting that a mix-up occurred at t
    12·1 answer
  • An example of working memory is
    10·1 answer
  • The waste product of respiration in animals is
    11·2 answers
  • hypothesize a mechanism to explain how tissues respond to insulin in different ways, even tisses that have the same amount of re
    11·2 answers
  • Select non-beta-lactam phosphoric acid agent is used today as an alternative treatment for urinary tract infections acused by en
    7·1 answer
  • What are unicellular prokaryotes that live in dust?
    5·1 answer
  • Identify the NOUN PHRASES in the sentence below:
    15·1 answer
  • Why did the united states ban the use of ddt
    5·2 answers
  • The law of conservation of energy states that
    10·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!