1answer.
Ask question
Login Signup
Ask question
All categories
  • English
  • Mathematics
  • Social Studies
  • Business
  • History
  • Health
  • Geography
  • Biology
  • Physics
  • Chemistry
  • Computers and Technology
  • Arts
  • World Languages
  • Spanish
  • French
  • German
  • Advanced Placement (AP)
  • SAT
  • Medicine
  • Law
  • Engineering
Komok [63]
3 years ago
8

The nucleoside analogue acyclovir, which is used to treat herpes simplex virus (HSV) infections, lacks a 3′ hydroxyl group (–OH)

. Predict what will happen if the host cell DNA polymerase incorporates a molecule of acyclovir into an elongating strand of HSV DNA.

Biology
1 answer:
Dima020 [189]3 years ago
6 0

Answer:

There won't be any functional viral DNA synthesis

Explanation:

First of all, you must consider that the HSV has a double-stranded, linear DNA genome. Furthermore, the DNA skeleton is made of the 5'-3' phosphodiester bond. In other words, the 5-phosphat of a nucleotide will bond the 3' OH of the Deoxyribose (see image).

Therefore, if you add a molecule which lacks the 3' OH, such as acyclovir, and has a similar chemical structure to a regular nucleotide, the DNA polimerase will be able to add acyclovir to the main backbone of the viral genome. All in all, you'd be ''cheating'' the DNA pol.

Hence, wherever acyclovir was integrated, there won't be any chance to form a 5'-3' phosphodiester bond. The protomolecule will not be stable and will soon be degradated.

You might be interested in
Glycerol and other organic compounds with an -ol ending is called
AleksAgata [21]
Alcohol like ethanol
6 0
3 years ago
James Watson and Francis Crick with, the help of Rosalind Franklin and others, determined that the shape of the DNA molecule was
zysi [14]
Shaped like a twisted ladder
3 0
3 years ago
Read 2 more answers
New inheritable characteristics would least<br> likely result from
Vikentia [17]

Answer:

Mutations that occur in muscle and skin cells

Explanation:

3 0
3 years ago
HELP! What type of transport does not require energy to move molecules across the plasma membrane?
svet-max [94.6K]

Answer:

Bilayer

Explanation:

IDK

7 0
3 years ago
Read 2 more answers
Each child born to a particular set of parents has probability 0.25 of having blood type o. if these parents have 5 children, wh
Taya2010 [7]
Use binomial distribution with p=0.25, n=5, x=2
P(X=x)=C(n,x)p^x (1-p)^(n-x)

P(X=2)=C(5,2) 0.25^2 0.75^(5-2)
=10*0.0625*0.421875
=0.26367

So the probability of 2 of 5 children having type-O blood from these parents is 0.26367.

7 0
3 years ago
Other questions:
  • Phytoplankton populations are most abundant in the
    12·1 answer
  • A client with cancer of the larynx is receiving external radiation therapy of the neck. which side effect related specifically t
    5·1 answer
  • The MCB operon encodes the following four core proteins: MCB250, MCB251, MCB252 and MCB253. MCB354 is encoded by a separate gene
    8·1 answer
  • Select the correct answer.
    14·1 answer
  • Which of the following is a true statement regarding microclimates?
    10·2 answers
  • Hi Katie. Thanks for you email.
    10·2 answers
  • Help me please! thanks
    14·1 answer
  • Explain positive negative and zero acceleration​
    15·1 answer
  • PLEASE HELP ILL GIVE BRAINLIEST
    13·1 answer
  • Don't copy and paste from other question answers plss. I'm giving 40 points
    14·1 answer
Add answer
Login
Not registered? Fast signup
Signup
Login Signup
Ask question!