Tay-Sachs disease is a human genetic abnormality caused by insufficient activity of a hydrolytic enzyme called hexosaminidase A.
This results in cells accumulating and becoming clogged with very large and complex lipids. Based on your knowledge of the functions of the various cellular organelles, which organelle must be involved in this condition?
They are spherical sac-like organelles that contain lytic enzymes that destroy aged and unwanted cells. They contain hydrolytic enzymes that destroy GM2, gangliosides a class of glycosphingolipid that are produced by the nerve cells. Mutations in the HEXA gene that leads to the translation of hexosaminidase A causes the genetic abnormality, Tay-Sachs.
<span>D. Temperature and pH can affect how enzymes work.</span> The action of enzymes can be affected by many factors including temperature, pH and ionic strength. Optimum pH differs per enzyme. Enzymes can be destroyed by heat more than the allowed optimum temperature.
