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KIM [24]
4 years ago
9

Tay-Sachs disease is a human genetic abnormality caused by insufficient activity of a hydrolytic enzyme called hexosaminidase A.

This results in cells accumulating and becoming clogged with very large and complex lipids. Based on your knowledge of the functions of the various cellular organelles, which organelle must be involved in this condition?
Biology
1 answer:
Feliz [49]4 years ago
6 0

Answer:

<u>lysosomes</u>

Explanation:

They are spherical sac-like organelles that contain lytic enzymes that destroy aged and unwanted cells. They contain hydrolytic enzymes that destroy GM2, gangliosides a class of glycosphingolipid that are produced by the nerve cells. Mutations in the HEXA gene that leads to the translation of hexosaminidase A causes the genetic abnormality, Tay-Sachs.

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In addition to identifying the genetic material, the experiments of Avery, MacLeod, and McCarty with different strains of Strept
guajiro [1.7K]

Answer:

DNA may be taken up by bacterial cells and be active.

Explanation:

To understand Avery, MacLeod, and McCarty's experiment, it is important to know Frederick Griffith's precursor experiment. The microbiologist worked at the British Ministry of Health's Pathology Laboratory with pneumococci (commonly known as the bacterium Streptococcus pneumoniae, then known as Pneumococcus, which causes pneumonia), which were previously classified into several types. When cultured in petri dishes in the laboratory, the pneumococci that synthesize their capsules generate 'smooth' colonies. Subcutaneous injection of liquid culture of these pneumococci into mice causes their death.  However, in vitro culture also allows the emergence of rough colonies', whose bacteria have lost the ability to synthesize mucopolysaccharide (and therefore have no capsules). Rough mutants could no longer be classified with sera and, moreover, lost their virulence: mice inoculated with them remained alive, unlike inoculated with smooth pneumococci.

The nature of Griffith's transforming principle remained unclear until the work of Avery, MacLeod, and McCarty. They repeated the in vitro transformation of pneumococci at the Rockfeller Institute for Medical Research, but replaced heat-dead cells with a purified fraction of smooth bacterial extract (unable to cause disease alone) and treated the material with different enzymes, each capable of destroying a specific type of macromolecule.  Experience has shown that this fraction retained its transforming capacity when treated with protein or RNA degrading enzymes, but lost that ability when treated with DNA degrading enzymes. These results indicated that the chemical nature of the 'transforming principle' was DNA.

Thus, we can conclude that in addition to identifying genetic material, Avery, MacLeod and McCarty experiments with different strains of Streptococcus pneumoniae demonstrated that DNA can be absorbed by bacterial cells and be active.

8 0
4 years ago
I WILL BRAINLIEST AND 5 STARS AND THANKS AND FOR 25 POINTS/PT
IrinaVladis [17]

Answer:

Magma

Explanation:

This rock is made  of cooled magma

6 0
3 years ago
Read 2 more answers
Question 1 (1 point) Question 1 Unsaved
IgorC [24]

question 1 is B

QUESTION 2 IS C

question 3 is a

question 4 is b

question  is d

question 8 is b

6 0
3 years ago
How can you describe the nucleus in protein synthesis?.
AURORKA [14]
The Nucleus & Its Structures
Therefore, the nucleus houses the cell's DNA and directs the synthesis of proteins and ribosomes, the cellular organelles responsible for protein synthesis. The nuclear envelope is a double-membrane structure that constitutes the outermost portion of the nucleus.
7 0
3 years ago
Indicate whether each of the following descriptions is true of microtubules (MT), microfilaments (MF), intermediate filaments (I
qwelly [4]

Answer:

(a) Microfilaments

(b) Microtubules

(c) Microtubules

(d) Microfilaments

(e) Intermediate filaments

(f) Microfilaments, intermediate filaments, microtubules

(g) Microfilaments, microtubules

(h) Microfilaments, intermediate filaments, microtubules

(i) Microtubules, microfilaments

(j) Microtubules

Explanation:

Microtubules (MTs) are dimers of the protein tubulin (alpha- and beta-tubulin subunits) and they are major components of the cytoskeleton. MTs play diverse cellular roles including, mechanical support (cytoskeleton), transport, motility, chromosome segregation, etc. Microfilaments (MFs) are protein filaments that also form part of the cytoskeleton in eukaryotic cells. MFs consist of G-actin monomers assembled in linear actin polymers, and their functions include mechanical support, cytokinesis, changes in cell shape, amoeboid movement, endocytosis and exocytosis, etc. MFs associate with the protein myosin to generate muscle contractions. Actin filaments/MTs assembly from monomeric actin/tubulin is caused due to energy expenditure, where ATP/GTP bound to actin/tubulin is hydrolyzed during polymerization. Finally, intermediate filaments (IFs) are a type of cytoskeletal element composed of a heterogeneous group of structural elements, and they are not found in all eukaryotes. The primary function of the IFs is to contribute to the mechanical support for the plasma membrane where these filaments come into contact with other cells and/or with the extracellular matrix. The IFs are not directly involved in cell movement. All 3 types of cytoskeletal elements (microfilaments, intermediate filaments, microtubules) can be visualized by fluorescence microscopy when cells express chimeric MT/IF/MF.–GFP fusion proteins.

8 0
3 years ago
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