i think you mean antibiotic ... but Alexander Fleming was the one who advanced the antibiotic (world) and was responsible for creating these categories of medicine... this affected the 20th century because millions of people use antibiotics everyday and without them... many diseases would still affect people without a cure
To explain the "no west" comment, in 1812 the American "west" only reached as far as the Mississippi River.
The northern states were heavily involved in international trade, having the ports and ship building yards. The men who sailed on those ships were likewise mostly from the north and were the ones being impressed into the British navy. The agrarian south's interests lay entirely in the production of tobacco, cotton, sugar, sorghum and a few other large cash crops. The commerce was mostly within America and they had little interest in shipping issues.
Answer: North-eastern Africa + Near East. A space between Egypt and Mesopotamia. First civilizations were born there, it was there were (probably) agricultural revolution started, where first writing were invented. The first civilized people we are able to identify there are Sumerians and pre-Sumerians (in spite of that we do not know many things about them).
Explanation: territories of today´s Egypt, Izrael, Palestine, Lebanon, Syria, Jordania, Iraq and partly Turkey.
You need to Paste the Chart you are talking about in order for me to answer it