An antibody made against the antigen tetanus toxoid (tt) reacts with it even when the tt is denatured by disrupting all disulfid

Question

3 years ago

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An antibody made against the antigen tetanus toxoid (tt) reacts with it even when the tt is denatured by disrupting all disulfid

e bonds. Another antibody against tt fails to react when the tt is similarly denatured. The most likely explanation can be stated as follows:

Biology

1 answer:

mylen [45] · Answer 1 · 2021-12-25T10:20:08+03:00

Answer;

-The first antibody is specific for the primary amino acid sequence of TT, whereas the second is specific for conformational determinants.

Explanation;

-Antigen-antibody reaction, is a specific chemical interaction between antibodies produced by B cells of the white blood cells and antigens during immune reaction.The specificity of the binding is due to specific chemical constitution of each antibody.

-The amino acid sequence in the tips of the "Y" varies greatly among different antibodies. This variable region, composed of 110-130 amino acids, give the antibody its specificity for binding antigen. The variable region includes the ends of the light and heavy chains.