Genetic Inheritance: Calculate probability of two children having the same genotype for achrondoplasia Achondroplasia is a commo
n form of dwarfism caused by autosomal dominant mutation in the fibroblast growth factor receptor 3 (Fgfr3) gene. If a person with achondroplasia (Aa) married and had children with a person of normal height, what is the probability that both their first child and second child would have achondroplasia?
The correct answer is - 1/2 or 50% for first and second child to be affected.
Step-by-step explanation:
Achondroplasia is an autosomal dominant disorder. Autosomal dominant disorder refers to the presence of a single copy of the defective gene that is enough to lead to dwarfness.
A cross of achondroplasia (Aa) parent to a person of normal height (aa) result in half of their children will be affected with dwarfism and the other half will be normal.
a cross between affected or dwarf and normal parent
Aa X aa
Punnett square:
a a
A Aa Aa
a aa aa
Aa- dwarfness
aa- normal height
The probability that both their first child and second child would have achondroplasia is
What you have to find is LCM(least common multiple in order to find the lcm all you have to do is list all the multiples and find their common multiple.
