Any atom at the ground state has its orbital levels fill from the bottom (close to the nucleus) – up. The inner orbitals are of lower energy state and fill first because the atoms ‘likes’ to exist in the low energy and more stable state. Only when the atom is in an excited state do some of the electrons in the lower orbital levels shift to higher unfilled orbitals.
Because we know that 15% of the population does not have the allele we can assume that at least 85% of the population has at least on copy of the dominant allele.
The Orthogenetic principle of development was put forward by Heinz Werner, in the year 1975.
It is a biological principle of development.
This principle of development states that all the aspects of the functioning of a living organism develop progressively from a less differentiated state to a more differentiated state.
Besides differentiation, there is also hierarchic integration and articulation of functioning such as perception, cognition, etc.
This leads to the development of more complex forms from a simple form.
Therefore, a single undifferentiated cell giving rise to the complex organized system is an example of the orthogenetic principle.