Background- In patients with intracranial artery stenosis, a long-term advantage of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been proven. We studied patients with intracranial arterial stenosis who were enrolled in the Cilostazol Stroke Prevention Study for Antiplatelet Combination trial, a randomized controlled trial in high-risk Japanese patients with ischemic stroke, to compare the efficacy and safety of DAPT with cilostazol and clopidogrel or aspirin to those of SAPT with clopidogrel or aspirin. Techniques and Outcomes In patients with ischemic stroke with symptomatic or asymptomatic intracranial arterial stenosis of at least 50% in a major intracranial artery, we compared the vascular and hemorrhagic events between DAPT and SAPT.
Patients were divided into two groups: 275 were given DAPT, while 272 were given SAPT. In contrast to SAPT, which had a higher risk of serious or life-threatening bleeding, DAPT had a lower risk of ischemic stroke (hazard ratio [HR], 0.47; 95% CI, 0.23-0.95); and a composite of stroke, myocardial infarction, and vascular mortality (HR, 0.48; 95% CI, 0.26-0.91). Conclusions In patients with intracranial artery stenosis following stroke, DAPT using cilostazol was superior than SAPT using clopidogrel or aspirin for the prevention of recurrent stroke and vascular events without raising bleeding risk.
<h3>What is
stroke?</h3>
When anything prevents blood flow to a portion of the brain or when a blood artery in the brain bursts, a stroke, also known as a brain attack, happens. The brain either ages or suffers harm in both scenarios. A stroke may result in permanent brain damage, chronic disability, or even fatality.
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Answer: d. angiotensin is detected by the hypothalamus.
Explanation:
Angiotensin is a hormone which causes the narrowing of the blood vessels. This helps in maintaining the blood pressure and also maintains the fluid balance in the body. The hormone acts on the brain. This hormone binds to the hypothalamus gland of the body, it stimulates the thirst and increases the demand for water intake. It also stimulates the release of antidiuretic hormone by the pituitary gland to increase the concentration of urine by preventing water loss.
The answer is <u>bleeding.</u>
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Risk the nurse is trying to prevent is bleeding.
What is bleeding?
Blood loss from the circulatory system is referred to as bleeding. Small cuts and abrasions to severe cuts and amputations are examples of possible causes. Body injuries can also cause internal bleeding, which can range in severity from modest (visible as superficial bruising) to significant hemorrhage.
In order to stop serious external or internal bleeding while waiting for emergency medical assistance, first aid is essential. Applying direct pressure to the wound, maintaining the pressure using pads and bandages, and, if feasible, lifting the damaged limb above the level of the heart are all first aid measures to manage external bleeding.
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