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Novosadov [1.4K]
3 years ago
6

What is the difference between asteroids and comets?

Biology
1 answer:
yan [13]3 years ago
7 0

Answer:

the main diffrence between asteroids and comets is their composition, as in, what they are made of. Asteroids are made up of metals and rocky material, while comets are made of ice, dust and rocky material. Both asteroids and comets were formed early in the history of the solar system about 4.5 billon years ago.

Explanation:

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Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis. Cell Death Differ. 2020,
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Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.

Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.

However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.

meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.

We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.

Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.

Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.

Learn more about breast cancer here : brainly.com/question/6747562

#SPJ4

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