Question

Angela is curious about how Clomid works to stimulate her ovaries. Her doctor told her that this drug works by "tricking the brain into thinking that the levels of estrogen in the body are low." Which of the following statements help explain why this would lead to a stimulation of the ovaries?
a. Clomid is a drug that inhibits the effect of FSH stimulating follicle development in the ovaries
b. Clomid prevents estrogen from exerting negative feedback, so LH and FSH levels remain high and continue to stimulate the ovaries
c. Clomid produces strong negative feedback on the brain, which leads to a drop in FSH and LH levels.
d. Clomid blocks the effect of FSH on the ovaries. The ovaries respond by increasing their production of estrogen.

Answer 1

Answer:

b. Clomid prevents estrogen from exerting negative feedback, so LH and FSH levels remain high and continue to stimulate the ovaries

Explanation:

Clomifene, also known by its commercial name Clomid, is a drug used to stimulate ovulation, and therefore used in fertility treatment. Clomid is a drug that works on estrogen receptors in order to stimulate the secretion of gonadotrophin by the pituitary gland, and by blocking negative feedback of estrogen steroid hormones (estradiol), thereby increasing the concentration of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). A high FSH concentration leads to the growth of ovarian follicles, whose rupture results in ovulation.