Individuals with these mutations typically have familial hypercholesterolemia.
These genes provide information for the formation of the low-density lipoprotein receptor, a receptor that binds to low-density lipoproteins (LDLs). LDLs carry the cholesterol in the blood and regulate the amount of cholesterol in the circulation. Mutations to these genes either reduce the number of receptors or cause several disruptions to their function. This results in high blood cholesterol levels and in a higher risk for heart disease.
Cloning is a process of producing genetically identical organisms through the techniques of biotechnology. Reproductive cloning of animals involves the somatic cell nuclear transfer in which the nucleus from an adult donor cell is transferred to an egg cell from which the nucleus has been removed. It is then incorporated into the uterus of a surrogate animal.
Pet cloning is not acceptable because of the following reasons-
(1) Its a very expensive procces with a high rate of failure.
(2) The clones produced tend to develop health problems. Large Offspring Syndrome (LOS) with very large organs is observed showing problems with blood flow and breathing with respect to heart and lungs, renal failure and other complicated issues.
(3) The clones are susceptible to skeletal abnormalities, higher rates of infection and tumour development. This results in a high mortality (death) rates.
(4) Since a surrogate mother is involved in the process of cloning, they experience a lot of health problems while carrying the embryos and sometimes it can be even killed.
Thus, cloning of pets is not acceptable as it affects both the cloned animal and the surrogate mother which is not preferred. Instead, adopting a homeless pet will provide shelter to another animal with a better nourishment.
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