I think it might be C, as the genome is specific to an individual, so the gene pool is that for the population, I suppose.
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Well, biotic factors are living things in an ecosystem such as animals or insects. Abiotic factors are non living things in an ecosystem such as sunlight or temperature. I would say biotic factors would be more harmful since this includes bacteria or other diseases, not many abiotic factors would pose a great threat to the entire human species. Hope this helped.