Pancreatitis is an inflammation of the pancreas that may be caused by years of heavy consumption of alcohol of gall stones. The pancreas plays major important roles such as secreting digestive juices into the small intestines, which help to digest fats, proteins, and the carbohydrates in food. It also release hormones insulin and glucagon that regulate the blood sugar. Pancreatitis is characterized by a pancreas being inflamed, therefore when this happens the body's normal complex coordination is disrupted and the enzymes in the pancreas are prematurely activated before they exit the organ, which results in these enzymes digesting the pancreatic tissue.
An example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation is option B: replacement of a polar amino acid with another polar amino acid at the protein's surface.
A frequent and well-known example of a missense mutation is the blood condition sickle-cell anemia. Missense mutations exist in the DNA at a single location in sickle-cell anemia patients. A different amino acid is required in this missense mutation, which also alters the overall structure of the protein. Similarly, replacement of a polar amino acid by another polar Ami no acid at the protein's surface is a missense mutation causing change in a single site.
A neutral mutation is one whose fixation is unrelated to natural selection. Therefore, the independence of a mutation's fixation from natural selection can be used to define the selective neutrality of a mutation.
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Complete question is:
Which example of a missense mutation in a protein-encoding gene would most likely be a neutral mutation?
a) Replacement of a polar amino acid with a nonpolar amino acid at the protein's outer surface
b) Replacement of a polar amino acid with another polar amino acid at the protein's surface
c) Replacement of a polar amino acid with another polar amino acid in the protein's interior
d) Replacement of a polar amino acid with a nonpolar amino acid in the protein's interior
Answer:
The post-transcriptional modifications in the mRNA produced as a result of the transcription in eukaryotes provide many advantages to the mRNA.
The two post-transcriptional modifications are the addition of 7-methylguanosine cap at 5' end of mRNA called capping whereas the addition of the poly(Adenyl) tail at 3' end called tailing.
The advantages of capping are:
1. Protection of nascent mRNA from the degradation.
2. Recognition by transcription factors helps in translation.
The advantages of tailing are:
1. Protection of the mRNA from enzymatic degradation in the cytosol.
2. Transcription termination
3. Export of the mRNA from the nucleus
