Low birth weight, premature birth, miscarriage (fetus dies before the 20th week of pregnancy), birth defects (hearing issues, or heart defect)
Its stabilising. Since the selection pressure is against the extremes which are the normal blood and the sickle cell anaemia.
4 billion years ago the temperature was much higher due to repeated volcanoes and hot gases present in the atmosphere. There weren't any live forms on earth. ... The atmosphere had a different concentration of gases on the earth. There were no life sustaining gases.
Maybe because of global warming and the glacier water melting makING it bigger and deeper. (I hope this is the answer you are looking for)