Answer:
a. Odds ratio = 1.58
b. Inasmuch the odds ratio is greater than 1, this means that higher odds of melanoma exist in people exposed to indoor tanning, than in those not exposed to indoor tanning
Explanation:
For case study
Let 'a' represent the total population of people with melanomia = 696
Let 'b' represent the total number of people with melanomia exposed to indoor tanning = 1107 – 696 = 411 people
For control study
Let 'c' represent the total population = 1500
Let 'd' represent the total number of people not exposed to indoor tanning = 1500 - (0.428 * 1500)
= 1500 - 723
Total number of people not exposed to indoor tanning = 777 people
a. Odds ratio = (a/b) / (d/c) = (696/411) / (777/723)
= 1.69 / 1.07 = 1.58
b. Inasmuch the odds ratio is greater than 1, this means that higher odds of melanoma exist in people exposed to indoor tanning, than in those not exposed to indoor tanning.
Answer:
Indivisuals with producing an abnormal form of extracellular protein fibrillin are suffering from Marfan syndrome ehich is caused by genetic mutation in the FBN1 gene.
Explanation:
Gene mutations in FBN1 gene results in the production of an abnormal extracellular matrix fibrillin-1 protein that cannot function properly. These gene mutations basically reduce the amount of fibrillin-1 produced by the cell, alter the structure of fibrillin-1, or causes the impairment of the transport of fibrillin-1 out of the cell.
As a result, protein is poorly incorporated into extracellular matrix. Hence, indivisuals with Marfan syndrome present following symptoms
Tall stature.
Disproportionately long arms, legs and fingers.
Sternum either protrudes outward or dips inward.
Arched palate and crowded teeth.
Heart murmurs.
Extreme nearsightedness.
