Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
Answer:
Lionfish are rapidly consuming many smaller fish species along the coast at depths up to 90 meters.
Explanation:
Lionfish is an invasive species that has been successfully established in the Atlantic Ocean. It is a tropical species that lives mostly in reefs and rocks that provide protection. It <u>i</u><u>nhabits waters from the coast to 50 meters deep. </u>
Because of its high densities in the Atlantic, Lionfish is a promoter of ecological, economic, socio-cultural consequences. They only have a few predators and consume a high diversity of prey items. They produce an ecological imbalance in the trophic chains of the marine ecosystem. When competing with native piscivores, they imbalance the dynamics of fish communities in coral reefs and mangroves. The <u>density of young and herbivores fishes has decreased because of their predation by the lionfish</u><u>.</u> By <u>predating on algae eating fishes</u>, they provoke a sharp increase in algae populations, which produces serious damages in the coral reefs, enhancing their mortality. The main consequences of these damages are marine biodiversity loss, water quality decrease, ecosystem recovery difficulty, and impacts on food provisioning for many other ocean species.
...............................................
The looping of DNA around histone proteins... a. Produces the characteristic helix shape of the DNA b. Allow the room for cellular machinery to reach all genes so they may be transcribed c. Compacts the DNA allowing a large amount of DNA to fit into the cell d. PreventS the DNA from becoming kinked and breaking e.