Answer:
PFFT this might help? sorry if not mate
Explanation:
Cell cycle checkpoint controls play a major role in preventing the development of cancer [see Sherr, 1994, for a more detailed discussion]. Major checkpoints occur at the G1 to S phase transition and at the G2 to M phase transitions. Cancer is a genetic disease that arises from defects in growth-promoting oncogenes and growth-suppressing tumor suppressor genes. The p53 tumor suppressor protein plays a role in both the G1/S phase and G2/M phase checkpoints. The mechanism for this activity at the G1/S phase checkpoint is well understood, but its mechanism of action at the G2/M phase checkpoint remains to be elucidated. The p53 protein is thought to prevent chromosomal replication specifically during the cell cycle if DNA damage is present. In addition, p53 can induce a type of programmed cell death, or apoptosis, under certain circumstances. The general goal of p53 appears to be the prevention of cell propagation if mutations are present. The p53 protein acts as a transcription factor by binding to certain specific genes and regulating their expression. One of these, WAF1 or Cip1, is activated by p53 and is an essential downstream mediator of p53-dependent G1/S phase checkpoint control. The function of p53 can be suppressed by another gene, MDM2, which is overexpressed in certain tumorigenic mouse cells and binds to p53 protein, thus inhibiting its transcriptional activation function. Other cellular proteins have been found to bind to p53, but the significance of the associations is not completely understood in all cases. The large number of human cancers in which the p53 gene is altered makes this gene a good candidate for cancer screening approaches.
Coevolution happens when the genetic development between two or more species affects the evolution of each other. An example would be hummingbirds and bird-pollinated (ornithophilous) flowers. The ornithophilous flowers give nourishment to the birds with their nectar that has high sugar content. The birds in return aids in the pollination of these flowers.
The best description about the brain stem is: it is the most important organ of our body's survival. It connects the brain and the spinal cord, controls the vital organs like the lungs and heart and it also coordinates the many essential body reflexes.
The correct answer is dehydration. Hope this helps.
<span>Though I was considered an absolute monarch, I always tried to do my best for the Prussian people. I allowed for freedom of the press and religion and made the Prussian educational system one of the best in Europe. I did not believe in the divine right of kings and just thought of myself as a citizen like everyone else.
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The ruler that fits these descriptions is definitely <span>Frederick the Great.
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