Explanation:
In the megasporan- gium of each ovule, the megasporocyte divides by meiosis, producing four megaspores. One survives and forms a female gametophyte. Fertilization: In nucleus of developing endosperm-- Double fertilization occurs. One sperm fertilizes the egg, forming a zygote.
Peak oil affects the lifestyle of organisms to a major extent. It is directly to the overproduction of higher levels of toxic compounds when ingested by organisms through air leads to problems like respiratory damage, cancer risk, liver damage, reproductive threat, etc.
<h3>What is Peak oil?</h3>
Peak oil may be defined as the speculative point in time when the global production of oil acquires its maximum rate.
The steps that should be taken to avoid energy shortages in a post-peak -oil future are as follows:
- Increase the dependency on solar energy.
- Limit the use of non-renewable sources of energy.
- Save major aspects of energy for the future.
- Conserve and plant more trees.
- Individuals need to make good habits of the utilization of energy-saving components and appliances that consume very less energy.
Therefore, it is well described above.
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Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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Answer:
kinetic energy is a energy of motion. At a given temperature, individual particles of a substance have a range of kinetic energies. The motion of particles theoretically ceases at absolute zero.