Question

For most ketones, hydrate formation is unfavorable, because the equilibrium favors the ketone rather than the hydrate. However, the equilibrium for hydration of hexafluoroacetone favors formation of the hydrate. Provide a plausible explanation for this observation.

Answer 1

Answer:

Hydrated form of hexafluoroacetone is highly stable.

Explanation:

Hydrated form of hexafluoroacetone is highly stable due to presence of two five membered ring structures formed through hydrogen bonding between F and H (in -OH group).

Due to this stable structure, $H_{2}O$ can not escape the hydrated form and goes back to keto form.

The structure of hydrated form of hexafluoroacetone has been shown below.