Answer:
<h2>
Through production of news cell-surface proteins with a different molecular structure by each new generation. Letter B</h2>
Explanation:
The life cycle of theses paratises extracellular alternate between the salivary glands of the insect transmitter and the blood of the mammal. During the set prior to the entry into the host, the metacylic parasites express a dense over formed by the Variant Surface of Glycoprotein, after entering to the mammal host they transform into a morphology that stays in the bloodstream.
<em>The parasites have to manipulate hosts cells in order to avoid the production of antimicrobial molecules and to benefit from growth factor production.</em>
<em>Intracellular protozoa have a remarkable adaptive capacity as they are able to resist killing by remodelling the phagosomal compartments where they reside and by interfering with the signalling pathway that leads to cellular activation. </em>
Answer:
Phosphorylation
Methylation
Explanation:
Histone mobilization deals with the covalent bonding of several functional groups to the free nitrogens in the R-groups of lysine in the N-terminal tail.
DNA transcription can be controlled or altered via 'methylation' on the histones. Methylation is the mode of transferring methyl group to amino group of histone proteins that form the nucleosomes, which result to chromosomes formation through wrapping of DNA double helix around it. Histones methylation can either increase or decrease genes transcription. Chromatin modification is known to stimulate neural pathways that are essential for long memories and learning.
Histones phosphorylation is associated transcriptional activation. It deals with the transfer of phosphate group to amino acids of the proteins. Phosphate group known to be negatively charged, when transferred to amino acids of the histone proteins, it creates a repulsive force with the negatively charged phosphates of the DNA backbone. It can occur in serine, tyrosine and threonine. The enzymes kinases activate phosphorylation, while protein phosphatases remove phosphate groups.
Answer:
Phase III
Explanation:
The given condition fall in the trial phase (Phase III) of cinical study which aims to:
- Determine drug's effectiveness (primary goal)
- Determine long-term drug safety
- Confirm findings
In Phase III, randomised, double-blind, placebo-controlled, parallel group study is majorly to evaluate the efficacy and safety of placebo in episodic migraine prevention in children (6 to < 12 years of age) and adolescents (12 to < 18 years of age).
The trial consists of four phases: screening; double-blind therapy period for 24 weeks in which placebo or Erenumab is given to subject as dose 1, dose 2 or dose 3 (based on the participant's body weight) once a month via subcutaneous injection; optional dose level blinded extension phase (40 weeks) which involves subjects recieve dose1, 2 and 3 of placebo, and at last it follows a safety follow-up phase for 12 weeks (after 16 weeks of the last dose of investigational drug).
Hence, the clinical phase is phase III.
Genetic information is found in DNA, which is found in the nucleus. it could also be chromosomes, however.
The 31 spinal nerve pairs are organized geographically by spinal region. There are eight pairs of cervical nerves (C1-C8), twelve pairs of thoracic nerves (T1-T12), five pairs of lumbar nerves (L1-L5), five pairs of sacral (S1-S5), and one pair of coccygeal nerves.
<h3>What number of nerves make up a pair?</h3>
The cranial nerves, a collection of 12 paired nerves, are located at the back of your brain. Your cranial nerves transmit electrical signals to your brain, face, neck, and body.
<h3>What are the 31 pairs of spinal nerves used for?</h3>
The peripheral nervous system, which consists of 12 cranial nerves and 31 pairs of spinal nerves, transmits nerve impulses from the central nervous system (CNS) to the rest of the body to control bodily activities.
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