B
(without the control you won't know what a normal result would be without the independent variable).
circulatory
The lungs and respiratory system work closely with the circulatory system to make sure oxygen reaches all the cells of our body.
<span>Natural selection is a process by which organisms that are better adapted to their environment tend to C. evolve new traits. Evolution is a process of change through time. There are several mechanisms of evolution, such as natural selection, mutations, migrations, and genetic drift. Natural selection is the mechanism by which species adapt to their environment to increase their chance of survival and reproduction. It can result in progress and cause some organisms to evolve new traits they need. </span>
Mosunetuzumab is a T-cell reliant bispecific antibody that binds to CD3 and CD20 to trigger T-cell mediated B-cell death.
However, cytokine release syndrome, which has the potential to limit dose and efficacy, can result from powerful immune stimulation with T-cell focused treatments.
We created a novel mechanistic model of immune and antitumor responses to the T-cell bispecifics (mosunetuzumab and blinatumomab), taking into account the dynamics of B- and T-lymphocytes in circulation, lymphoid tissues, and tumors, in order to better understand the mechanisms underlying safety and efficacy as well as to explore safety mitigation strategies.
Using mosunetuzumab nonclinical and blinatumomab clinical data, the model was created and validated. The initial step-fractionated dose was projected to minimize systemic T-cell activation and cytokine release without impairing tumour response.
Simulations described the mechanisms underlying the observed cell and cytokine (IL6) dynamics. The Phase I clinical study for mosunetuzumab was changed to a step-fractionated treatment schedule as a result of these findings, allowing for the safer administration of greater dosages.
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