Question

Aminoglycosides: Select one: a. attach to the 30S ribosomal subunit and disrupt protein synthesis. b. are metabolic analogs of PABA and block folic acid synthesis. c. damage cell membranes. d. block peptidases that cross-link glycan molecules.

Answer 1

Answer:

The correct answer is a. attach to the 30S ribosomal subunit and disrupt protein synthesis.

Explanation:

Aminoglycosides are the antibacterial drugs that are usually used against the gram-negative bacterial infection, for example, gentamycin, streptomycin, etc.

These drugs bind on the 30s ribosomal subunits of the ribosome and allow the misreading of the codon sequence present on mRNA by ribosome which results in the incorporation of a wrong amino acid in the growing polypeptide chain that disrupts the protein synthesis.

The other function that aminoglycosides perform are breakdown of RNA, translation inhibition, interference with electron transport chain, etc. Therefore the correct answer is a.