If your lymphatic system stopped working properly fluid would build in your tissues and cause swelling. You could get infections, blockage and even cancer. If your immune system stopped working properly too then you would most likely die. Since your lymphatic system is down and your immune system is down it would weaken your body tremendously meaning the smallest cold could cause death.
Joes way of hanging out with the wrong people can be a big factor of the problem with his substance addiction
Using positive actions while communicating with others can affect you drastically, if you are a naturally positive person, then being a positive peer will cause less conflict. If you are continuously being rude or negative on purpose, it can cause conflict and violence, which is not good for your mental health. Higher stress levels also cause a number of health-related illnesses