He demonstrated that SCD and sickle cell trait were due to the presence of abnormal 8-globin polypeptides in red blood cells. He demonstrated that the electrophhoretic mobility of B-globin from patients with SCD was different from that of healthy individuals. He demonstrated that both parents of multiple patients with SCD had low levels of sickled red blood cells. He hypothesized that SCD was a recessive trait and that the parents of patients with SCD would be heterozygous carriers. He demonstrated that the difference between B-globin polypeptides in individuals who were healthy and those with SCD is an amino acid substitution. He performed a peptide fingerprint analysis on B-globin from individuals with 84 84 and 89 88, which identified the segment of B-globin that was changed by the BS mutation. James Neel Linus Pauling Vernon Ingram
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Answer:
For example, a haploid human nucleus (i.e. sperm or egg) normally has 23 chromosomes (n=23), and a diploid human nucleus has 23 pairs of chromosomes (2n=46). A karyotype is the complete set of chromosomes of an individual.
Explanation:
A linear shaped piece of DNA strand is obtained when a plasmid is cut HindIII, Apa1, and Sma1.
Explanation:
Restriction enzymes are endonucleases which enzymatic proteins which can cut a DNA at specific sequences at particular recognition sites. The sequences recognized by these enzymes are usually palindromic that occurs for a definite length (6 bp, 4 bp, or 8 bp).
They can either be blunt cutters or sticky end cutters. APA1, SMA1, and HindIII are all restriction enzymes which can cut a circular plasmid at specific locations.
These restriction enzymes bind with the DNA at specific locations and cuts them to give linear strands of DNA either with a blunt or a sticky end.
