Axonal guidance is the process through which axons reach their proper targets in the brain. Researchers hypothesize that the wil
d-type PTP gene product mediates proper axonal guidance by inactivating the Abl gene product. Which experimental observation would best support this hypothesis?
Suppression of Abl reduces the severity of abnormal axonal guidance in PTP mutants
Explanation:
Axon guidance is a neural development subfield relating to the mechanism by which neurons send out axons to meet their right targets.
ABL gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes. PTPs are known to signal a number of cellular processes, including cell development, differentiation, mitotic cycle, and oncogenic transformation.
Suppression of Abl reduces the severity of abnormal axonal guidance in PTP mutants.
