Question

A chromosome has undergone a translocation that has completely deleted its centromere region, preventing association with spindle fibers. Other than this loss of sequence, the remaining DNA of this chromosome is undamaged. What will be the fate of this cell?

Answer 1

Answer:

The cell will not pass the M checkpoint because its chromosomes will not associate with spindle fibers. or if the cell goes complete division, then the homologous chromosomes will go into either daughter cell.

Explanation:

 As in the cell cycle, there are various checkpoints, which checks the cell in many steps like G1/S checkpoint, G2, M  etc. They check the integrity of the genome, if there is any defect in the DNA/chromosome, it arrest the cell cycle.

Centromere is the region on the chromosome which binds with spindle fibers and is used in the separation of chromosomes during anaphase of cell cycle. If there is deletion of centromere, then the separation of chrmosome will be affected. Then the homologous chromosome can either go into one of the daughter cell, so one cell will get 2n+1 and other will get 2n-1.