You can think of this question like the photos attached above.
Also, a friendly reminder (I am sure that you know this already though) that variables cannot be capital letters (only lowercase). I used to make (and still make) this mistake a lot when writing equations, so I just thought that this reminder might be helpful.
Find the horizontal and vertical distance between the points. First, subtract y2 - y1 to find the vertical distance. Then, subtract x2 - x1 to find the horizontal distance.