Protein-protein interactions within the CARMA1-BCL10-MALT1 complex:
- The T-cell receptor and B-cell receptor-dependent NF-B induction and lymphocyte activation are mediated by the CBM complex, which is made up of the proteins CARMA1, BCL10, and MALT1.
- Each of the proto-oncoproteins CARMA1, BCL10, and MALT1 is a somatic gain-of-function mutation or chromosomal translocation, and dysregulation of CBM signaling is a characteristic of numerous lymphoid malignancies, including Activated B-cell Diffuse Large B-cell Lymphoma.
- Moreover, a number of immunological dysregulation diseases have been linked to both gain- and loss-of-function germline mutations in CBM complex proteins.
- Over the past ten years, careful examination of the interactions of CBM components has yielded a wealth of detailed structural knowledge.
- Here, we discuss important discoveries about the molecular nature of these protein-protein interactions that have helped the research develop a detailed understanding of how these proteins come together to form high-order filamentous CBM complexes.
- Approaches to therapeutic suppression of the CBM complex have thus far centered on obstructing MALT1 protease activity in order to treat lymphoid malignancy and/or autoimmunity.
- The structural effects of MALT1 protease inhibitors on significant protein-protein interactions are also reviewed in detail.
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Answer;
-To release or generate energy
Explanation;
-The main reason that cells carry out cellular respiration is to release or generate energy that drives cellular processes such as growth, and reproduction.
-Cellular respiration is the process by which animal and plant cells break down nutrients such as glucose to generate energy in the form of ATP, that is used to drive cellular processes such as growth, reproduction and transport among others.
Answer:
Organ is made up of cells and tissues that perform larger functions.
Explanation:
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A cellular function that is shared between carbohydrates and lipids is energy production.
Carbohydrates like glucose will be oxidized to pyruvic acid in glycolysis which gets transported to mitochondria where it gets converted to acetyl co-a. Acetyl co-a then enters Kreb's cycle in which Nadh and Fadh molecules are formed these molecules are oxidized in the electron transport chain to form ATP which is an energy currency of a cell. Lipids are oxidized through the beta-oxidation pathway to form acetyl co-a which enters the Krebs cycle to form Nadh and Fadh molecules which are oxidized in the electron transport chain to form ATP. This explains how carbohydrates and lipids share the same function which is energy production.
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