Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
Trophic cascades are powerful indirect interactions that can control entire ecosystems. Trophic cascades occur when predators limit the density and/or behavior of their prey and thereby enhance survival of the next lower trophic level.
Explanation:
their u go
Answer:
The answer is sunlight.
Explanation:
Sunlight is captured from the plants leaves and that energy is used to break down water into hydrogen and oxygen.
According to the 2011 Earth Science Reference Table, Selenite Gypsum has an approximate hardness of 2.
The hardness of calcite is 3.
The hardness of apatite is 5 according to the Moh's hardness scale.
The hardness of diamond is 10.
Answer:
F10.229 is the answer.
Explanation:
is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
