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ankoles [38]
3 years ago
7

A researcher has identified a mutant strain of yeast whose histones are unable to be acetylated. Which of

Biology
1 answer:
d1i1m1o1n [39]3 years ago
4 0

Answer:

The correct answer is c the mutant will show decreased levels of gene expression.

Explanation:

Histone acetyl transferase is an enzyme that helps in the transfer of acetyl group to the epsilon -NH2 group of lysine reside of histone proteins that surrounds the DNA molecule of chromosome.

  This results to make the target DNA more assecible for transcription mediated by RNA polymerase resulting the gene expression.

 On the other hand the mutant in which histones are not acetylated,transcription rate decreases as the non acetylated DNA is less assecible to RNA polymerase.

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In colorectal cancer, some tumor suppressor genes are inactive. This is an important factor resulting in uncontrolled cell divis
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Answer/Explanation:

(1) a mutation in the coding region, resulting in an inactive protein

To check to see if there is a mutation, you could extract the DNA from the cancer cells and then perform PCR to amplify the gene of interest. You could then perform sanger sequencing and compare the sequence to the normal gene to see if a mutation is present. To test the effect of the mutation, you would want to see if an active protein has been formed.

To see if a normal sized protein has been formed, you could perform a western blot, comparing the protein band to the WT protein band. If the protein is absent or much smaller, it is likely not a functional protein.

(2) epigenetic silencing at the promoter of the gene, resulting in reduced transcription.

To check for changes in the epigenetic landscape of the promoter, you could perform chromatin immunoprecipitation by extracting the chromatin from the tumour cells and using antibodies for different chromatin marks to see what has changed between the normal cells and the tumor cells. E.g. H3K9me3, H3K27me3. You would perform a pull down with the antibody of interest and then PCR for your promoter to specifically look at changes at that gene compared to normal cells. To test DNA methylation, you could perform bisulfite sequencing.

To see how transcription is affected, you could extract RNA from the tumor and normal cells, and compare the levels of RNA between the two samples by qRT-PCR

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3 years ago
Why do scientists believe Neanderthals had some interbreeding with AMHs?
Gelneren [198K]

Explanation:

However, in 2016 researchers published a new set of Neanderthal DNA sequences from Altai Cave in Siberia, as well as from Spain and Croatia, that show evidence of human-Neanderthal interbreeding as far back as 100,000 years ago farther back than many previous estimates of humans' migration out of Africa (Kuhlwilm Dec 11, 2020

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A student wants to know the effect a mutation might have on a species' survival. The change causes a rabbit to have mottled brow
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Answer:a

C

E

Explanation:

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Phylogeny uses communal ancestry to group organisms and further nest them into bigger and bigger groups. This is also a study of evolutionary relationships among organisms. Visible characteristics such as anatomical and behavioral traits, as well as biochemical (enzymes, proteins, pigments, etc.) and genetic traits (nucleotide sequences) that need more modern techniques to detect.  

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If someone adds millions of small fish to a lake, how would the number of big fish change?
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It depends on what the big fish and the small fish eat
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