Question

A cancer, acute lymphoblastic leukemia, is caused by chromosomal translocation. How does this condition arise?

Answer 1

Answer:

By translocation of chromosome 9 and chromosome 22.

Explanation:

Acute lymphoblastic leukemia (ALL) is a type of blood cancer, which leads to increased production of immature lymphocytes.

This condition can arise due to translocation between chromosome 9 and chromosome 22. During this, ABL1 gene of chromosome 9 and BCR gene of chromosome 22 fuse together and Philadelphia chromosome.

Fusion gene made from ABL1-BCR represents an oncogene, which codes for a mutated protein. This protein causes impaired DNA binding with uncontrolled cell division that can cause cancer.

Thus, the correct answer is 'translocation.'

Answer 2

Is it due to attachement of bronken part of one chromosome to another. I hope this helps.