The probability of two independent events occurring together is the Quotient of the probability of each event occurring separately.
<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
B. a volcano that erupts in blasts of the pyroclastic matter. D. would be wrong because the shield volcano can have explosive eruptions but they are generally quiet
Answer:
increase anxiety; decreased vulnerability to overreact to stress
Explanation:
Serotonin (5-HT) is a natural neurotransmitter that carries signals between nerve cells (neurons) throughout the body. This neurotransmitter (serotonin) is responsible for regulating many biological functions (e.g., mood, digestion, sleep, etc). Moreover, it has been shown that there is an association between low cerebrospinal fluid 5-hydroxyindole-acetic acid (5-HIAA, the principal serotonin metabolite in the brain) levels and the risk of developing depression or destructive behaviors. In addition, serotonin concentration can also be elevated in situations of anxiety and/or stress. Antidepressants such as Prozac, Zoloft and Paxil act as serotonin uptake inhibitors that increase serotonin concentration at the synaptic site. Like other drugs, these antidepressants may lead to increase anxiety and decrease the vulnerability to react to stress by downregulating sensitivity to serotonin released during natural stress situations.
The answer is A//////////