Inosinate (IMP) serves as common precursor for the biosynthesis of AMP and GMP. Biosynthesis of AMP from inosinate includes the insertion of amino group from aspartate in GTP dependent manner to form adenylsuccinate followed by its conversion into AMP (adenylate).
Conversion of inosinate into GMP includes dehydrogenation of inosinate into xanthylate (XMP) which is then converted into GMP in a reaction catalyzed by XMP-glutamine amidotransferase enzyme.
