There is proof of it. Such as fossils, records, videos, etc. Dinosaurs and Thylacines for example. Both of these have been extinct for quite some time. Although there is footage of some Thylacines there isn't any of any Dinosaurs. However, there is fossils and bones found from Dinosaurs. There has been fossils from many extinct animals dating back millions of years, therefore proving its a common event through history.
B] Nutritional Status
you can't control your age or the environmental conditions so B is the best answer
Elderlies
Orphans
Patients
I think the correct answer would be genetic modification. It is the most controversial technique that is used by many farmers as this method produce high quality products in large volumes. These products are called genetically modified organisms or GMO's.