Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Answer:
No. 5% of ciprofloxacin oral suspension for this child exceeds the therapeutic range.
Explanation:
Single dose of ciprofloxacin suspension shall be 400 mg
the pediatric oral dose is 10-20 mg/kg and body weight of child is 55 lb.
1 kg is 2.2 lb= 55÷ 2.2 = 25 kg
minimum required dose for child is 25 × 10= 250 mg
maximum required dose for child is 25 × 20 = 500 mg
1 teaspoonful is 5000 mg.
500 mg ÷ 5000 mg = 0.1 tsp
Hence, the dose exceeds the therapeutic range.
Answer:
The control group is defined as the group in an experiment or study that does not receive treatment by the researchers and is then used as a benchmark to measure how the other tested subjects do.
The nurse would include what as possible adverse effects is Vomiting and Dysuria and Anorexia.
<h3>What is an example of anorexia?</h3>
Even when you are extremely small physically, you might think you are overweight. If you have anorexia, you might use odd eating habits to cope with stress, worry, and low self-esteem. You might feel better in control at all times if you cut back on your food intake. This problem affects women more than men do.
<h3>Who is afflicted by anorexia?</h3>
Girls and women are more likely as boys and men to suffer from anorexia. Younger women and girls are also more likely than older women to suffer from anorexia. Girls typically experience anorexia at 16 and 17. Young women in their early twenties and adolescent girls between the ages of 13 and 19 are particularly at risk. Anorexia nervosa has uncertain exact causes. Nevertheless, the illness can run in families; young girls with a parent.
To know more about Anorexia visit:
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MyPlate is divided into sections of approximately 30 percent grains, 30 percent vegetables, 20 percent fruits and 20 percent protein, accompanied by a smaller circle representing dairy
