If your body has developed a tolerance to a medication you're taking, it means the medication at your current dose has stopped working as effectively as it once did. It might mean your body becomes used to the medication, and you don't get the same benefits or effects as before. Drug tolerance is indicative of drug use but is not necessarily associated with drug dependence or addiction. The process of tolerance development is reversible and can involve both physiological factors and psychological factors.
The pKa represents the pH of the medium at which the zwitterionic amino acid assumes most stable ionic form due to structural stabilization. As the pKa is dependent upon the environmental factors of the solution around the amino acids, a change in their structure and localization can cause change in the pKa of the protein. Thus, the answers can be found as below:
Part A: Decrease (As the lysine is basic in nature, it will tend to stabilize the electrostatic interaction and weak interactions between the acidic amino acids and hydrogen bonds in the viscinity, thus lowering the pH and hence pKa of the protein)
Part B: Increase (As the carboxyl group is acidic in nature, removal of it will tend to increase the pKa since the basic amino acids will tend to accumulate more negative charge in their viscinity)
Part C: Increase (As glutamic acid is an acidic amino acid, its shift from outside to a non-polar site will prevents its ionization and hence the pKa will tend to shift from slightly acidic to slightly basic, hence increase)
Om said that he had a lot more than a little more money than his wife and I was in the middle of a meeting with the guy that was going through the house and I had to go back and forth with him
<span>B. The have been Earth's only hominine for the last 24,000 years.
After the unknown eradication of the Homo Neanderthals, Homo Sapiens became the only homonine for the last 24,000 years. That is to say, that modern humans are the result of the evolution of homo sapiens to homo sapiens sapiens.</span>
