<span>Lafora disease is the most severe teenage-onset progressive epilepsy, a unique form of glycogenosis with perikaryal accumulation of an abnormal form of glycogen, and a neurodegenerative disorder exhibiting an unusual generalized organellar disintegration. The disease is caused by mutations of the EPM2A gene, which encodes two isoforms of the laforin protein tyrosine phosphatase, having alternate carboxyl termini, one localized in the cytoplasm (endoplasmic reticulum) and the other in the nucleus. To date, all documented disease mutations, including the knockout mouse model deletion, have been in the segment of the protein common to both isoforms. It is therefore not known whether dysfunction of the cytoplasmic, nuclear, or both isoforms leads to the disease. In the present work, we identify six novel mutations, one of which, c.950insT (Q319fs), is the first mutation specific to the cytoplasmic laforin isoform, implicating this isoform in disease pathogenesis. To confirm this mutation's deleterious effect on laforin, we studied the resultant protein's subcellular localization and function and show a drastic reduction in its phosphatase activity, despite maintenance of its location at the endoplasmic reticulum.
I got my information from </span>https://www.ncbi.nlm.nih.gov/pubmed/14722920
D. POPS.
Your answer is D because pesticides have aldrin, chlordane, .... which are all POPS.
The initiating event in the development of nephrotic syndrome is a derangement in the glomerular membrane that causes increased permeability to plasma proteins.
Nephrotic syndrome can be understood as a kidney disorder in which the glomeruli filter of the kidney gets damaged due to which it is unable to filter the proteins and passes an excess amount of protein in the urine.
Glomeruli filter consists of clusters of small blood vessels in the kidneys that function in filtering the waste and excess water from the blood. It also sweeps the blood protein which is necessary to maintain the correct amount of fluid in the body, from seeping into the urine. But when it gets damaged glomeruli stop sweeping the protein from the urine as a result too much blood protein leaves your body, leading to nephrotic syndrome.
Learn more about Nephrotic syndrome here
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Answer: Carbon dioxide
Krebs cycle, also known as the citric acid cycle or TCA, uses 1 glucose molecule to produce 2 acetyl Co-A molecules which in turn are broken down to release:
1) 4 CO2
2)2FADH2
3) 6NADH
4) 2ATP