Answer: There are two factors that determine the urine flow rate during an osmotic diuresis: the rate of excretion of effective osmoles in the urine and the effective osmolality of the interstitial compartment of the renal medulla.
The normal range for 24-hour urine volume is 800 to 2,000 milliliters per day (with a normal fluid intake of about 2 liters per day).
Down syndrome causes a distinct facial appearance, intellectual disability, developmental delays, and may be associated with thyroid or heart disease.
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