Prader-Willi syndrome (PWS) is a gentic disorder which has an impact on numerous physiological systems. PWS affected individuals (specifically babies) experience delayed growth, significant hypotonia (low muscle tone), and feeding issues. It does effect circadian rhythms in mice models.
SNORD116, often referred to as HBII-85, is a non-coding RNA (ncRNA) molecule that contributes to the alteration of other small nuclear RNAs (snRNAs). Unlike the majority of other snoRNAs, SNORD116 is not significantly complementary to ribosomal RNA and is expressed widely in the brain (but not in PWS patients).
According to the studies, SNORD116 cause sleep defect in patients with Prader-Willi syndrome. Same observation was seen in mouse models too. Paternal expression of SNORD116 is thought to be a potential gene for the sleep disruptions/circadian rhythm’s that the majority of PWS sufferers.
To learn more about circadian rhythm click here
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The box stopped moving because the force stopped pushing . The average speed of the box would be 5 meters per second
The likelihood that the first two offspring of the cross will have congenital analgesia would be 1/16
<h2>Autosomal Recessive Traits</h2>
For autosomal recessive traits, two recessive alleles are needed for the trait to manifest while one recessive allele means heterozygosity.
In this case, let us assume that congenital analgesia is represented by the allele b; heterozygous individuals will, thus, be Bb.
Bb x Bb
BB Bb Bb bb
Probability of producing unaffected offspring = 3/4
Probability of producing affected offspring = 1/4
Likelihood of the first two offspring having congenital analgesia = probability of first having congenital analgesia and the second having congenital analgesia
= 1/4 x 1/4
= 1/16
More on genetical probabilities can be found here: brainly.com/question/851793?referrer=searchResults
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