The correct statement is liver cells possess transcriptional activators that are different from those of lens cells.
<h3>What are Transcriptional activators?</h3>
Transcriptional activators are specific protein sequences capable of activating gene expression.
These transcription factors (transcriptional activators) act to regulate gene expression in target cells.
Transcriptional activators are factors that enable the expression of certain genes in particular cell types.
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That thing is called abrasion.
Hydro means water. which means the adding of water; it is digestion. it is the opposite process of dehydration synthesis which is removing water. synthesis hear means small to large so opposite processes. :)
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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