Question

. A man employed for several years in a fire extinguisher assembly factory becomes the father of a hemophiliac boy. There is no hemophilia in the pedigrees of the man’s ancestors and his wife’s ancestors. Another man, also employed for several years in the same assembly factory, has an achondroplastic dwarf child. There is no achondroplasia in the pedigrees of the man’s ancestors and his wife’s ancestors. Both men sue their employer for damages claiming that high levels of PFAS chemicals in their workplace caused mutations in their germlines. As a geneticist, you are asked to testify in court. What do you say about each situation? Does either plaintiff have a case? (Note: hemophilia is an X-linked recessive; achondroplasia is an autosomal dominant.)

Answer 1

Answer and Explanation:

As Hemophilia is a X-connected passive issue, i.e., may have transmitted when 2X from the mother have been transformed then her child will show the manifestations.  

X-connected recessive disorderss don't get transmitted from father to child.  

For another situation of acondroplasia which is an autosomal issue.  

Thus there is no commitment of sex-connected chromosomes.  

In this manner, their case can't be legitimized as a result of the method of legacy of the two disorders.