Raising the temperature will denature an enzyme so that it is no longer functional. Lowering the temperature will reduce the rate of the reaction so low as to make it seem non-functional. Altering the pH above or below its optimum pH will also reduce the enzyme's activity, and at extremes the enzyme may be permanently denatured.
3. is oxygen the others i would have to double check my book, so give me a minute and I'll try to put the rest in the comments
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Pompe is a disease in which u have a defect in the lysosome (an organelle found in every eukaryotic cell). The gene should be making a certain enzyme but it doesn't. This causes things to build up in cells that shouldn't be there. This type if disease is progressive and can be fatal. The treatment for this disease is very expensive. A person would need enzyme replacement therapy...which is not cheap. It will drastically affect a person's life. One can have progressive muscle weakness (where they require a walker or wheel chair), respiratory problems (where a breathing tube might be needed) , and heart defects.
<span>In the past, human populations were controlled by </span>Disease and Famine
