Sickle cell trait is not a disease; it is an inherited red blood cell condition that can affect athletes at all levels. While sickle cell trait is not a barrier to playing competitive sports, athletes with sickle cell trait have experienced significant physical distress, including collapse and death during intense exercise. Heat, dehydration, inadequate acclimatization, altitude and asthma can increase the risk for medical complications in athletes with sickle cell trait Through awareness, education and proper physical conditioning under the supervision of a primary athletics health care provider, athletes with sickle cell trait may safely achieve outstanding athletic performance