Answer:
Explanation:
Pharmacophore (pharmacology) - The molecular framework responsible for a drug's biological activity. According to IUPAC — A pharmacophore is the ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response.
Privileged structures are defined as molecular frameworks which are able of providing useful ligands for more than one type of receptor or enzyme target by judicious structural modifications.
1) The 1,4-dihydropyridine ring is present in many biologically important molecules that acts as an important scaffold for cardiovascular drug - a calcium antagonists and although it is technically not considered as a pharmacophore, it is considered as a privileged structure.
1,4-Dihydropyridine (DHP), belongs to the class of calcium antagonist that inhibits the influx of extracellular Ca+2 through the L-type voltage-dependent calcium channels.
A positional substitution in the 4-position is feasible in the heterocyclic ring which in turn culminates in various calcium channel antagonist activities and this heterocyclic ring is the common feature for various pharmacological activities such as anti-inflammatory activity, analgesic activity,
antihypertensive, antianginal, antitumor, antitubercular activity and antithrombotic .
Position on the heterocyclic ring binds to the L-type channel and also to N-type channel on membranes.
2.) The bioisosteres are not a suitable bioisostere for the traditional C-4 aryl or heteroaryl substitution which is necessary for calcium ion blockage thereby inhibiting it to function with the mechanism shared above.
The sun is 92.96 million miles away from the Earth. It is located in the middle of Earths rotation around it.
Business Impact Analysis
Business Impact Analysis (BIA) refers
to the method of determining the potential risks that a business will encounter
when disaster strikes. It is the first step in the contingency planning process.
Large businesses with strong disaster recovery planning programs put BIA into
their programs, making it one of the important stages. Unless BIA has been
conducted, the disaster recovery programs will not be fully developed since the
output of BIA will ascertain the strategies and policies that will be in the
disaster recovery program of the company.
Two techniques that are used in order to restore the biodiversity are the sawing of native seeds or planting individual plants, and the reintroduction of animal species native to the ecosystem.
The restoration of the biodiversity is practically trying to get an ecosystem in its initial, pre-destruction condition, and help it function without any human assistance after certain amount of time.
All restorations of the biodiversity are hard and take time, and there's no guarantee that the outcome will be as planned and wanted. Initially, there the sawing of native seeds and planting individual plants, which is crucial as the plants are the basis of the ecosystems. After that animal species are introduced, small and large, herbivores, omnivores, and carnivores. The people initially have to assist the functioning of the ecosystem, but the idea is to make it function properly over time on its own.
The answer should be advantame
