Explain how XY mice with a duplication of chromosome 1 develop ovaries and a female phenotype.

Biology

1 answer:

Dahasolnce [82]3 years ago

3 0

Answer:

Duplication of the Dax1 is associated to equivocal sex determination on how XY mice develop ovaries and a female phenotype which comes from strong expression of the homologous gene (Ahch) in the first stages of gonadal (and adrenal) differentiation.

Explanation:

Dose-Sensitive Sex Reversal Locus on Chromosome X, Gene 1 , DAX1∗ (officially, nuclear receptor subfamily 0, group B, member 1; NR0B1) is a member of the nuclear hormone receptor superfamily of transcription factors that functions primarily as a transcriptional repressor.

Duplication of the DAX1/NROB1 locus is associated with male-to-female sex reversal, that is ambiguous external genital differentiation ranges.

One X chromosome and one Y chromosome in each diploid cell of their bodies differencite males from females, who typically have two X chromosomes but XX males that are SRY-positive have two X chromosomes, with one of them containing genetic material from the Y chromosome, making them phenotypically male but genetically female.

DAX1 protein may be directly or indirectly involved in gonadal regulation of hypothalamic-pituitary function.

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