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1619, to Jamestown, Virginia
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In 1788, in the 78th paper of “The Federalist, Alexander Hamilton argued for judicial review by an independent judiciary as a necessary means to void all governmental actions contrary to the Constitution.
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The American Revolution was principally caused by colonial opposition to British attempts to impose greater control over the colonies and to make them repay the crown for its defense of them during the French and Indian War (1754–63)
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Brown v. Board of Education was a landmark case in which it was finally proven that segregation in institutions of education was highly unconstitutional, so you could say that that is the greatest effect since it made other schools become open for everyone as well.
When Pope Urban wanted to wage war against Muslims in the "holy land" Below is a map of the first crusade.