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Andrews [41]
3 years ago
13

How does Thermally Sensitive Liposomes Work?

Biology
1 answer:
Virty [35]3 years ago
7 0

Answer:

Thermosensitive liposomes (TSL) are promising tools used to deliver drugs to targeted region when local hyperthermia is applied (∼40–42°C) which triggers the membrane phase transformation from a solid gel-like state to a highly permeable liquid state. Selective lipid components have been used to in TSL formulations to increase plasma stability before hyperthermia and speed drug release rate after. Two generations of TSL technology have been developed. The traditional thermal sensitive liposomes (TTSL) have utilized DPPC and DSPC as a combination. The second generation, lysolipid thermally sensitive liposomes (LTSL) technology, has been developed with incorporation of lysolipids that form stabilized defects at phase transition temperature. LTSL maintains certain favorable attributes:

High percentage of lysolipids incorporation;

Minimum leakage for therapeutical drugs encapsulation;

Ultrafast drug release upon heating (3.5 times enhanced compared to TTSL). For example, ThermoDox, a commonly used LTSL drug for cancer, has been reported to release 100% of the encapsulated doxorubicin within 30s;

First and most successful formulation for intravascular drug release.

Explanation:

https://www.creative-biostructure.com/Lysolipid-Thermally-Sensitive-Liposomes-Production-612.htm

You might be interested in
Red foxes have three different types of coat color: red, cross, and black/silver. These coat colors are controlled by a single l
Anna [14]

Answer:

74%

Explanation:

The frequency in such cases (diallelic cases) is estimated by following formula which is attached in the image:

So as per our question, the frequency of the "R allele" as per data given below will be as under:

58 red-phase (RR)

32 cross-phase (RS)

10 black/silver-phase (SS) foxes

Total plants = 58 + 32 + 10 = 100

f(R) = 58 x 2 + 32/ 2 (58+32+10)

    = 116 + 32 / 200

     = 148/200

     = 0.74 i.e. 74%

3 0
3 years ago
The fluid mosaic model describes the plasma membrane as consisting of The fluid mosaic model describes the plasma membrane as co
andre [41]

Answer:

diverse proteins embedded in a phospholipid bilayer

Explanation:

According to fluid mosaic model the cell membrane is made of bilayer of phospholipid. Many proteins are embedded in this bi layer. Carbohydrate and cholesterol are also found in different forms. Carbohydrate can either be attached to the embedded protein in which case it is called as glycoprotein or it can be connected to the lipid molecule in layer and called as glycolipid.

Proteins can be found in two forms too. They can either be embedded in the layer i.e. they can penetrate single or both layers. These proteins are called as integral proteins. They can also be present on one side of the membrane and not penetrate the lipid bilayer in which case they are called as peripheral proteins.

8 0
3 years ago
Three cells each contain a 98% water wash were soaked in different solutions cell number one is so funny solution containing 100
stepladder [879]

Answer: Cell number one is an hypotonic solution, cell number two is an isotonic solution, and cell three is an hypertonic solution.

Explanation:

Cell number one which is a 98% water content is added the 100% water solution, water moves from low to high concentration. Therefore, the water moves from the solution into the cell, which is hypotonic.

Cell number two which is a 98% water content added with a 98% water solution. These two solutions are equal to one another, so the water does not move. This is isotonic.

Cell number three which is a 98% water content added with a 80% water solution. Water moves from high to low concentrations, so water moves from the cell to the solution. The water leaves the cell, which is an hypertonic.

6 0
3 years ago
Why can't astronomers measure the parallax of a star that is a million light years away?
motikmotik

One of the methods used widely to calculate the distance of nearby or closer objects in astronomy is Parallax. The distance of the stars are usually expressed in light years but the unit of distance is parsec or parallax second.  

                                        1 Parsec = 3.26 light years

Astronomers are not able to measure the parallax of a star that is a million light years away because the star is too far and the distance with which the start appears to move is too less to be calculated accurately.

6 0
3 years ago
If the genotype for hair color was B for brown and b for blonde, what would the genotype be for a person who was homozygous rece
horsena [70]
Homozygous means that it has the same alleles and lower case represents a recessive trait therefore the genotype for a homozygous recessive individual is: bb
6 0
3 years ago
Read 2 more answers
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