How does Thermally Sensitive Liposomes Work？

Biology

1 answer:

Virty [35]3 years ago

7 0

Answer:

Thermosensitive liposomes (TSL) are promising tools used to deliver drugs to targeted region when local hyperthermia is applied (∼40–42°C) which triggers the membrane phase transformation from a solid gel-like state to a highly permeable liquid state. Selective lipid components have been used to in TSL formulations to increase plasma stability before hyperthermia and speed drug release rate after. Two generations of TSL technology have been developed. The traditional thermal sensitive liposomes (TTSL) have utilized DPPC and DSPC as a combination. The second generation, lysolipid thermally sensitive liposomes (LTSL) technology, has been developed with incorporation of lysolipids that form stabilized defects at phase transition temperature. LTSL maintains certain favorable attributes:

High percentage of lysolipids incorporation;

Minimum leakage for therapeutical drugs encapsulation;

Ultrafast drug release upon heating (3.5 times enhanced compared to TTSL). For example, ThermoDox, a commonly used LTSL drug for cancer, has been reported to release 100% of the encapsulated doxorubicin within 30s;

First and most successful formulation for intravascular drug release.

Explanation:

https://www.creative-biostructure.com/Lysolipid-Thermally-Sensitive-Liposomes-Production-612.htm

You might be interested in

1.) Explain how you identified the chromosomes in order to place them in the correct pairs.

aivan3 [116]

Answer:

A chromosome is a DNA (deoxyribonucleic acid) molecule with part or all of the genetic material (genome) of an organism. Most eukaryotic chromosomes include packaging proteins which, aided by chaperone proteins, bind to and condense the DNA molecule to prevent it from becoming an unmanageable tangle. This three-dimensional genome structure plays a significant role in transcriptional regulation.Chromosomes are normally visible under a light microscope only when the cell is undergoing the metaphase of cell division (where all chromosomes are aligned in the center of the cell in their condensed form). Before this happens, every chromosome is copied once (S phase), and the copy is joined to the original by a centromere, resulting either in an X-shaped structure (pictured here) if the centromere is located in the middle of the chromosome or a two-arm structure if the centromere is located near one of the ends. The original chromosome and the copy are now called sister chromatids. During metaphase the X-shape structure is called a metaphase chromosome. In this highly condensed form chromosomes are easiest to distinguish and study.In animal cells, chromosomes reach their highest compaction level in anaphase during chromosome segregation.

Chromosomal recombination during meiosis and subsequent sexual reproduction play a significant role in genetic diversity. If these structures are manipulated incorrectly, through processes known as chromosomal instability and translocation, the cell may undergo mitotic catastrophe. Usually, this will make the cell initiate apoptosis leading to its own death, but sometimes mutations in the cell hamper this process and thus cause progression of cancer

8 0

4 years ago

Cell replication is important for reproduction of body cells and reproduction of gametes. Which type of reproduction occurs only

Oksi-84 [34.3K]

Answer:

meiosis

Explanation:

meiosis occurs in reproductive organs

8 0

3 years ago

Which is not a characteristic of living things? Organisms can adapt to changes. Organisms respond to changes. Organisms only nee

tresset_1 [31]

Not a characteristic of living things is organisms only need water.

3 0

3 years ago

What proportion of DNA molecules will contain any radioactivity after two rounds of replication?

Vladimir [108]

Answer: After two rounds of replication half of DNA molecules will contain one strand with radioactive nitrogen. And the other half will contain two strands with radioactive nitrogen.

Explanation:

In semi-conservative replication, two DNA molecules are created, each consisting of one strand of the original DNA and one new complementary strand. In other words, the DNA is formed from one old strand and one new strand. And the existing strands serve as a complementary mould to the new ones.

Meselson-Stahl's experiment involves growing the bacterium Escherichia coli in a medium containing radioactive nitrogen. Watson and Crick had predicted that DNA replication was semi-conservative, if so the DNA extracted from the bacteria would be somewhere in between the DNA extracted from the "normal" nitrogen medium and the radioactive nitrogen medium.

DNA replication, which occurs only once in each cell generation, requires many "building blocks", enzymes, and a great deal of energy in the form of ATP. The nucleotides, which are the building blocks of DNA, have to be assembled and available in the nucleus along with the energy to bind them together. Each nucleotide consists of three parts: a nitrogen-containing ring structure called a nitrogen base, a five-carbon sugar, and at least one phosphate group.

Through the action of DNA polymerase during replication, new nucleotides bind to the corresponding nucleotide of the original chain (A to T, C to G).

Since the DNA strands are anti-parallel, and replication proceeds only in the 5' to 3' direction on both strands, one strand will form a continuous copy, while the other will form a series of short fragments known as Okazaki fragments. The chain that is synthesized continuously is known as the forward chain and the chain that is synthesized in fragments is known as the backward chain.

Then, since replication is semi-conservative, the new strand will have nucleotides with "normal" nitrogen while the new strand created from that same DNA molecule will incorporate nucleotides with radioactive nitrogen. So, after two rounds of replication half of DNA molecules will contain one strand with radioactive nitrogen. And the other half will contain two strands with radioactive nitrogen.