Balboa claimed the entire Pacific ocean and all lands adjoining it for Spain.
Currently? probably overpopulation
In 1969 protesters for American Indian independence occupied the island "Alcatraz" of the coast of San Fransisco. They did this mainly to bring attention to the unfair treatment of Natives by the US government.
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Geography, including regional differences in soils, rainfall, and growing seasons was the primary cause of economic differences among the colonies in North America. A result of the encounter between Europeans and Native Americans was that new diseases were spread to Native American populations.
